Jaypirca is a brand-name oral tablet that’s prescribed for certain types of blood cancer, including lymphoma and leukemia. Jaypirca contains the active drug pirtobrutinib.

Specifically, Jaypirca is prescribed to treat the following types of blood cancer in adults:

Jaypirca is prescribed to adults who have received certain treatments for MCL, CLL, or SLL in the past. For more details about these uses, see the “Jaypirca uses” section below.

Drug details

You’ll find key information about Jaypirca below.

  • Drug class: Bruton tyrosine kinase inhibitor
  • Drug form: oral tablet
  • Generic available? no
  • Prescription required? yes
  • Controlled substance? no
  • Year of FDA approval: 2023
  • Accelerated approval? yes

Jaypirca is available only as a brand-name medication. It’s not currently available in generic form.

A generic drug is an exact copy of the active drug in a brand-name medication. Generics typically cost less than brand-name drugs.

The Jaypirca dosage your doctor prescribes will depend on several factors. These include:

  • other medical conditions you may have, including severe kidney impairment
  • other medications you may take, if they can interact with Jaypirca

The following information describes dosages that are commonly prescribed or recommended. However, be sure to follow the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Jaypirca comes as an oral tablet. It’s available in two strengths: 50 milligrams (mg) and 100 mg.

Dosage formantle cell lymphoma

The recommended dose for mantle cell lymphoma is 200 mg. You’ll take this dose once daily.

Your doctor may adjust your dosage based on how well your body tolerates the medication. If you develop certain side effects from Jaypirca, your doctor may pause treatment until your side effects are managed. When you restart the medication, your doctor may prescribe a lower dosage. This may help reduce the risk of side effects.

Dosage for chronic lymphocytic leukemia or small lymphocytic lymphoma

The recommended dose for chronic lymphocytic leukemia or small lymphocytic lymphoma is 200 mg. You’ll take this dose once daily.

Your doctor may adjust your dosage based on how well your body tolerates the medication. If you develop certain side effects from Jaypirca, your doctor may pause treatment until your side effects are managed. When you restart the medication, your doctor may prescribe a lower dosage. This may help reduce the risk of side effects.

About taking Jaypirca

Below you’ll find information about key dosage issues.

  • When to take: You should take Jaypirca once daily at the same time each day. Taking the medication at the same time of day helps keep a steady level of the drug in your body. This helps Jaypirca work effectively.
  • If you miss a dose: If you miss a dose of Jaypirca, your next steps depend on when your dose would have been due, as follows:
    • If you miss a dose by fewer than 12 hours, take the dose.
    • If you miss a dose by more than 12 hours, skip that dose. Then take your regular dose at your next scheduled time.
    • If you’re not sure whether to take or skip a missed dose, talk with your doctor or pharmacist for advice.
  • Taking Jaypirca with food: You can take Jaypirca with or without food.
  • Crushing, splitting, or chewing Jaypirca: You should not crush, split, or chew Jaypirca. Swallow each tablet whole with water.
  • Length of treatment: Jaypirca is meant to be a long-term treatment. But if your cancer gets worse or if you experience unmanageable side effects, your doctor may have you stop taking the drug.

Overdose

Do not take more Jaypirca than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.

What to do in case you take too much Jaypirca

If you think you’ve taken too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number or go to the nearest emergency room right away.

Jaypirca can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Jaypirca. These lists do not include all possible side effects.

For more information about the possible side effects of Jaypirca, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.

Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Jaypirca, you can do so through MedWatch.

Mild side effects

Below is a partial list of mild side effects of Jaypirca. To learn about other mild side effects, talk with your doctor or pharmacist or view Jaypirca’s prescribing information.

Mild side effects of Jaypirca can include:

Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.

* For more information about allergic reaction and Jaypirca, see “Allergic reaction” below.

Serious side effects

Serious side effects can occur while taking Jaypirca. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

  • Severe infections, such as COVID-19 and pneumonia. Symptoms can include:
    • chills
    • cough
    • shortness of breath
  • Bleeding, such as bleeding in the digestive tract or brain. Symptoms vary depending on where the bleeding occurs in the body, but can include:
    • vomiting blood
    • severe abdominal pain
    • rectal bleeding
    • stool that looks bloody or tar-like
    • dizziness
    • weakness
    • confusion
    • headache
  • Heart arrhythmias, including atrial fibrillation and atrial flutter. Symptoms can include:
  • High blood pressure. This doesn’t typically cause symptoms, but very high blood pressure may cause:
    • headache
    • chest pain
  • Severe cytopenia (low level of red blood cells, white blood cells, or platelets in your blood).
  • Increased risk of other cancers, such as skin cancer.
  • Severe allergic reaction.*

* For details about allergic reaction and Jaypirca, see “Allergic reaction” below.

ALLERGIC REACTION

As with most drugs, some people can have an allergic reaction after taking Jaypirca. This side effect was rare in clinical trials of this drug but can still occur.

Symptoms of a mild allergic reaction can include:

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

  • swelling under your skin, typically in your eyelids, lips, hands, or feet
  • swelling of your tongue, mouth, or throat
  • difficulty breathing

Call your doctor right away if you have an allergic reaction to Jaypirca, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

The Food and Drug Administration (FDA) approves prescription drugs such as Jaypirca to treat certain conditions.

Jaypirca for mantle cell lymphoma

Jaypirca is FDA-approved* to treat relapsed or refractory mantle cell lymphoma (MCL) in adults who have received certain treatments in the past for this condition. (“Relapsed” means that the cancer went away but came back. “Refractory” means that the cancer didn’t respond to past treatments.)

Jaypirca may be prescribed to individuals who have already received at least two types of systemic treatments for MCL, including a Bruton tyrosine kinase (BTK) inhibitor. (“Systemic” means that the entire body is exposed to the treatment, not just one area. Systemic treatments are typically either taken by mouth or given as injections.)

BTK inhibitors are a type of drug. Jaypirca belongs to this drug class. An example of another BTK inhibitor is ibrutinib (Imbruvica).

MCL is a fast-growing cancer that affects white blood cells in your lymph nodes. Lymph nodes are part of your immune system. They help detect and fight infections.

* Jaypirca received accelerated approval from the FDA for this use based on early clinical trial results. After additional clinical trials of Jaypirca for MCL have been done, the FDA will make a decision about the drug’s full approval.

Jaypirca for chronic lymphocytic leukemia or small lymphocytic lymphoma

Jaypirca is FDA-approved* to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults who have received certain treatments in the past for this condition.

Jaypirca may be prescribed to individuals who have already received at least two types of treatments for CLL or SLL, including a BTK inhibitor and a BCL-2 inhibitor.

BTK inhibitors are a type of drug. Jaypirca belongs to this drug class. An example of another BTK inhibitor is ibrutinib (Imbruvica). BCL-2 inhibitors are another type of drug. An example from this drug class is venetoclax (Venclexta).

CLL is a slow-growing cancer that affects white blood cells in the bone marrow and eventually spreads to the blood. SLL is a similar type of cancer, but it mainly affects white blood cells in the lymph nodes.

You can learn more about your condition by visiting our leukemia hub.

* Jaypirca received accelerated approval from the FDA for this use based on early clinical trial results. After additional clinical trials of Jaypirca for CLL and SLL have been done, the FDA will make a decision about the drug’s full approval.

Jaypirca and children

Jaypirca hasn’t been approved for use in children. It’s not known whether the drug is safe or effective for treating cancer in people younger than 18 years old.

Jaypirca can interact with several other medications. It can also interact with certain supplements as well as certain foods.

Before taking Jaypirca, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also, tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

Interactions with medications, foods, and supplements

Below is a list of medications, supplements, and foods that can interact with Jaypirca. This list does not contain all interactions that may occur with Jaypirca. If you have questions about interactions that may affect you, ask your doctor or pharmacist.

Medications that can interact with Jaypirca• bosentan (Tracleer)
• certain antifungal drugs, such as ketoconazole and itraconazole (Sporanox, Tolsura)
• efavirenz
• repaglinide
• rifampin (Rifadin)
• rosuvastatin (Crestor)
Vitamins or supplements that may interact with JaypircaSt. John’s wort
Foods that can interact with Jaypircagrapefruit

Alcohol interaction

Alcohol is not known to interact with Jaypirca.

However, drinking alcohol can cause some of the same side effects as Jaypirca, such as diarrhea. So drinking alcohol during Jaypirca treatment may increase the risk of this side effect or make it worse.

If you have questions about how much alcohol is safe to drink while taking Jaypirca, talk with your doctor or pharmacist.

As with all medications, the cost of Jaypirca can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Drug coupons: You can visit Optum Perks for price estimates of Jaypirca. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with any insurance copays or benefits.

Financial and insurance assistance: If you need financial support to pay for Jaypirca, or if you need help understanding your insurance coverage, help is available.

To learn more about saving money on prescriptions, check out this article.

Generic version: Jaypirca is not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs.

To save money on your Jaypirca prescription, explore these Optum Perks coupons.

Save on your Jaypirca prescription

Save on Jaypirca without insurance.

Enter your information:

Location

47201

Dosage

100mg jaypirca (60 Tablets)

Save money without using insurance

Simply show the Optum Perks coupon at your preferred pharmacy or order online and instantly save up to 80% without using insurance. The coupon doesn’t expire, so be sure to save it for refills.

Find your pharmacy
advertisement

Error

No pricing information found.

Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

Optum Perks and Healthline are subsidiaries of RVO Health.

Pricing source:Perks.optum.com

optum-logo

Was this helpful?

Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Jaypirca, talk with your doctor. They can tell you about other medications that may work well for you.

The following drugs are similar to Jaypirca:

If you can become pregnant, consider the following information about pregnancy, birth control, and breastfeeding.

Jaypirca and pregnancy

Jaypirca should not be taken during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before taking this medication. Your doctor may suggest birth control options to use during treatment with Jaypirca.

Jaypirca and birth control

Jaypirca may cause harm to a developing fetus if taken during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re taking Jaypirca.

Note: Sex and gender exist on spectrums. Use of the terms “female” and “male” in this article refers to sex assigned at birth.

For females taking Jaypirca

Females who can become pregnant should use birth control while taking Jaypirca and for at least 1 week after their last dose.

For males taking Jaypirca

The manufacturer of Jaypirca hasn’t provided any specific contraceptive recommendations for males taking the drug. Males taking Jaypirca whose sexual partners can become pregnant should talk with their doctor to discuss birth control needs during and after treatment.

Jaypirca and breastfeeding

Jaypirca should not be taken while breastfeeding.

If you’re currently breastfeeding or planning to do so, talk with your doctor before taking this medication. Your doctor will likely recommend other ways to feed your child during treatment with Jaypirca.

It’s not known for sure whether Jaypirca passes into breast milk. Because of the risk of harm if the drug does pass into breast milk, doctors recommend waiting at least 1 week after your last dose of Jaypirca before you breastfeed your child.

Here are answers to some frequently asked questions about Jaypirca.

How does Jaypirca work? And how long does it take to start working?

Jaypirca is prescribed to treat certain types of blood cancers. It works by blocking an enzyme in your body called Bruton tyrosine kinase (BTK). An enzyme is a type of protein that speeds up biochemical processes.

BTK is an enzyme that helps cells survive and grow. This includes healthy cells as well as cancer cells. Jaypirca works by blocking the action of BTK, which can slow or stop the cancer from growing.

Jaypirca starts working soon after you start treatment. However, it may take a few months before you and your doctor can tell whether your cancer is responding to the drug. To determine this, your doctor will have you get scans or other tests to check the status of your cancer.

Talk with your doctor to learn more about what to expect with Jaypirca treatment and how they’ll monitor your response.

Can Jaypirca cause long-term side effects?

Possibly, but there is limited information available about how long Jaypirca’s side effects may last. In most cases, if you develop a severe side effect during Jaypirca treatment, your doctor may have you pause the treatment until the side effect is managed. And they may have you restart the treatment at a lower dosage.

In clinical trials, some people developed other types of cancer while taking Jaypirca. (Jaypirca is prescribed to treat certain types of blood cancer.) The most common cancer type seen in these trials was nonmelanoma skin cancer. Other types of cancer included solid tumors, such as breast cancer, and melanoma.

Because of this risk, it’s important to take precautions to help prevent other cancers. This includes wearing sunscreen to protect your skin and getting regular preventive screenings for cancer, such as mammograms.

Talk with your doctor to discuss the possible risks and benefits of Jaypirca for your condition.

How does Jaypirca compare with Imbruvica?

Jaypirca and Imbruvica belong to the same drug class. (A drug class is a group of drugs that work in a similar way.) The class is called BTK inhibitors.

Jaypirca and Imbruvica are prescribed to treat some of the same types of cancer. However, they are currently approved by the Food and Drug Administration (FDA) to treat different types of cancer as well.

Jaypirca received FDA approval* in 2023. It’s prescribed to treat the following types of blood cancer in adults in certain situations:

Imbruvica received FDA approval** in 2013. It’s currently approved to treat the following conditions:

For CLL or SLL, one of the main differences is that doctors may prescribe Imbruvica as a first treatment. In contrast, doctors typically will only prescribe Jaypirca after someone has already tried at least two other types of treatments for CLL or SLL.

To learn more about how these medications compare, talk with your doctor or pharmacist.

* Jaypirca received accelerated approval from the FDA for this use based on early clinical trial results. After additional clinical trials of Jaypirca for CLL and SLL have been done, the FDA will make a decision about the drug’s full approval.
** Imbruvica received accelerated approvalto treat other conditions in the past, including MCL, but this approval was withdrawn in 2023.

This drug comes with several precautions.

Before taking Jaypirca, discuss your health history with your doctor. Jaypirca may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

  • active infection
  • recent or upcoming surgery or dental procedure
  • cardiovascular problems, such as high blood pressure or heart rhythm problems
  • severe kidney disease
  • bleeding problems
  • past allergic reaction to this or a similar drug
  • pregnancy
  • breastfeeding

Note: For more information about the potential negative effects of Jaypirca, see the “Jaypirca side effects” section above.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.