Vosevi (sofosbuvir/velpatasvir/voxilaprevir) is a brand-name drug prescribed for chronic hepatitis C in adults in certain situations. Vosevi comes as an oral tablet that’s typically taken once per day.

The Food and Drug Administration (FDA) has approved Vosevi to treat chronic hepatitis C in adults. Doctors prescribe Vosevi for specific types of hepatitis C virus (HCV) infection in people who have previously received other antiviral drugs.

Vosevi also belongs to the antiviral drug class. It’s not available in a generic version.

Keep reading for specific information about the dosage of Vosevi, including its strength and how to take the medication. For a comprehensive look at Vosevi, including details about its uses, see this article.

Note: This article describes the typical dosage for Vosevi provided by the drug’s manufacturer. When taking Vosevi, always follow the dosage prescribed by your doctor.

Read below for the recommended dosage of Vosevi and other details about the drug.

Vosevi form

Vosevi comes as an oral tablet.

Vosevi strength

Vosevi comes in one strength. Each tablet contains 400 milligrams (mg) of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir.

Typical dosage

The following information describes the dosage that is commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for chronic hepatitis C

Doctors may prescribe Vosevi to treat chronic hepatitis C in certain situations.

If your doctor prescribes Vosevi, your starting dose will likely be one tablet taken daily. This is the recommended dosage of Vosevi for people with chronic hepatitis C. It’s also the maximum dose of Vosevi that’s recommended.

For more information about your dosage, talk with your doctor.

Length of treatment

Vosevi is taken short term for chronic hepatitis C. Doctors typically prescribe Vosevi as a 12-week course of treatment.

Talk with your doctor if you have questions about how long you can expect to take Vosevi.

Vosevi comes as a tablet you swallow whole. Do not divide, crush, chew, or place the tablet in water.

It’s best to take Vosevi with food (either a meal or a snack). This helps your body absorb the medication. You should also take your dose around the same time each day. This helps maintain a steady level of the drug in your body so Vosevi can work effectively.

If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

If you have questions about how to take Vosevi, talk with your doctor or pharmacist.

Note: You should not take any antacids that contain aluminum or magnesium less than 4 hours before or after you take Vosevi. This is because these antacids can affect how well your body absorbs Vosevi. Taking these antacids with Vosevi could lower the amount of Vosevi in your body. This could make the drug less effective for treating your condition. Taking these antacids at least 4 hours apart from when you take Vosevi helps minimize their effect on Vosevi levels.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Vosevi in an easy-open container. They also may recommend tools that can make it easier to open bottles.

If you miss a dose of Vosevi, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose and take your next scheduled dose. Do not take two doses to make up for the missed one. If you’re not sure whether you should take a missed dose or skip it, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you don’t take more Vosevi than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

If you take more than the recommended amount of Vosevi

Call your doctor right away if you believe you’ve taken too much Vosevi. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Vosevi and dosage.

Is the dosage of Vosevi similar to the dosage of Epclusa?

Yes, the forms and how often you take each drug are similar, but there are some differences. Vosevi and sofosbuvir/velpatasvir (Epclusa) come as an oral tablet taken daily. Epclusa is also available as oral pellets.

Doctors prescribe both medications to treat chronic hepatitis C in adults. Epclusa is also used in certain children. Both Vosevi and Epclusa contain the active ingredients sofosbuvir and velpatasvir. But Vosevi has a third active ingredient (voxilaprevir) that Epclusa does not have.

Your doctor will prescribe the drug and the dosage that’s right for you. To learn more about how these drugs compare, talk with your doctor.

How long does it take for Vosevi to start working?

Vosevi starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. But your doctor will monitor you during treatment to check whether the drug is working to treat your condition. Doctors typically prescribe Vosevi as a 12-week course of treatment.

Talk with your doctor if you have questions about what to expect with Vosevi treatment.

The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Vosevi for you, they’ll prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Vosevi without your doctor’s recommendation. If you have questions about the dosage of Vosevi that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Vosevi. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.