Trodelvy interactions: Alcohol, medications, and other factors

Before you start treatment with Trodelvy, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Trodelvy interacts with supplements, herbs, or vitamins, see the “Trodelvy and other interactions” section below.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a table of drugs that can interact with Trodelvy. Keep in mind that this table doesn’t include all drugs that may interact with Trodelvy. Some of these interactions are described in detail just below in “Drug interactions in depth.”

* For details about Trodelvy’s side effects, see this article.
† For details about this interaction, see the “Drug interactions in depth” section below.

In some cases, factors or conditions could prevent your doctor from prescribing Trodelvy due to the risk of harm. These are known as contraindications. The contraindications of Trodelvy include:

Having had an allergic reaction to Trodelvy or any of its ingredients

If you have had an allergic reaction to Trodelvy or any of its ingredients, your doctor will likely not prescribe Trodelvy. Receiving the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.

Note: Before you start treatment with Trodelvy, it’s important to tell your doctor if this contraindication applies to you. They can determine whether to prescribe Trodelvy.

There aren’t any known interactions between Trodelvy and alcohol. However, your doctor may advise you to avoid or limit alcohol consumption during Trodelvy treatment.

This is because drinking alcohol during treatment with the drug may worsen some of Trodelvy’s side effects. For example, you may experience worsened dizziness, headache, nausea, or vomiting.

If you have questions about drinking alcohol during Trodelvy treatment, talk with your doctor.

Here’s a closer look at certain drug interactions of Trodelvy.

Certain HIV drugs

Protease inhibitors are prescribed to treat HIV.

Interaction result: Receiving Trodelvy while taking certain protease inhibitors can increase the risk of side effects from Trodelvy.

Interaction explained: Trodelvy is broken down in your body by a specific enzyme. (An enzyme is a type of protein.) Certain protease inhibitors slow down the activity of this enzyme. As a result, receiving Trodelvy with certain protease inhibitors can lead to a high level of Trodelvy in your body. This may increase your risk of side effects from Trodelvy.

Examples of protease inhibitor drugs: Protease inhibitors that may interact with Trodelvy include ritonavir (Norvir) and atazanavir (Reyataz).

Steps you or your doctor may take: Before you begin Trodelvy treatment, tell your doctor about any protease inhibitors you take. Your doctor can tell you whether your specific protease inhibitor may interact with Trodelvy. If it does, your doctor may prescribe a cancer treatment other than Trodelvy.

Certain tyrosine kinase inhibitors

Tyrosine kinase inhibitors (TKIs) are prescribed to treat certain cancers.

Interaction result: Receiving Trodelvy while taking certain TKIs can increase the risk of side effects from Trodelvy.

Interaction explained: Certain TKIs slow down the activity of an enzyme that helps your body break down Trodelvy. Receiving Trodelvy with certain TKIs can cause Trodelvy to break down more slowly, leading to a high level of Trodelvy in your body. This may increase your risk of side effects from Trodelvy.

Examples of TKI drugs: Here are some TKIs that may interact with Trodelvy:

• regorafenib (Stivarga)
• nilotinib (Tasigna)
• sorafenib (Nexavar)
• erlotinib

Steps you or your doctor may take: Before starting Trodelvy treatment, tell your doctor about any TKIs you take. Your doctor can tell you whether your TKI interacts with Trodelvy and whether it’s safe to take these drugs together. If your TKI may interact with Trodelvy, your doctor may prescribe a different cancer treatment.

Certain seizure drugs

Seizure drugs are prescribed to treat seizures related to certain conditions, including epilepsy. In some cases, seizure drugs are also prescribed for mental health conditions and nerve pain.

Interaction result: Receiving Trodelvy while taking certain seizure drugs can make Trodelvy less effective.

Interaction explained: Certain seizure drugs speed up the activity of an enzyme that helps your body break down Trodelvy. Receiving Trodelvy with these drugs can cause Trodelvy to break down more quickly, leading to a low level of the drug in your system. This may make Trodelvy less effective for treating your condition.

Examples of seizure drugs: Phenytoin (Dilantin, Phenytek) and carbamazepine (Carbatrol, Tegretol, others) are seizure drugs that may interact with Trodelvy.

Steps you or your doctor may take: Before receiving Trodelvy injections, tell your doctor about any seizure drugs you take. They can tell you whether it’s safe to take these medications together. If your seizure drug interacts with Trodelvy, your doctor may recommend a different cancer treatment instead.

Trodelvy may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Trodelvy.

Trodelvy and supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Trodelvy and herbs

There are no specific reports of herbs interacting with Trodelvy. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Trodelvy treatment.

Trodelvy and vitamins

There are no specific reports of vitamins interacting with Trodelvy. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Trodelvy.

Trodelvy and food

There were no reports of food interactions with Trodelvy. If you’d like to learn more about eating certain foods during treatment with Trodelvy, talk with your doctor.

Trodelvy and vaccines

There aren’t any known interactions between Trodelvy and vaccines. However, Trodelvy may weaken your immune system. Vaccines work by exposing your immune system to a certain bacterium or virus. This helps prepare your body to fight off an illness caused by the bacterium or virus.

If your immune system is weakened, vaccines may not work as well to protect against infection. In some cases, you could become sick or develop symptoms of the illness the vaccine is meant to prevent.

Before starting Trodelvy, talk with your doctor or pharmacist about any vaccines you may need.

Trodelvy and lab tests

Trodelvy isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.

TRODELVY INTERACTION WITH CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Trodelvy. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Trodelvy. The effects of cannabis may affect how well you stick to your Trodelvy treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Trodelvy. Before you start this drug, be sure to talk with your doctor about your health history. Trodelvy may not be the right treatment option for you if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Trodelvy include:

• Carrying the UGT1A1 gene: Your risk of certain side effects from Trodelvy may be higher if you carry a gene called UGT1A1. These side effects include neutropenia* and anemia. Your doctor may test you for this gene before prescribing Trodelvy. If you carry the UGT1A1 gene, your doctor will decide whether Trodelvy is right for you.
• Liver problems: It isn’t known whether Trodelvy is a safe treatment option for people with moderate or severe liver problems, such as liver failure. Your doctor may test your liver function before prescribing the drug. If the tests show a moderate or severe liver problem, your doctor may prescribe a different cancer treatment instead.
• Allergic reaction: If you’ve had an allergic reaction to Trodelvy or any of its ingredients, your doctor will likely not prescribe Trodelvy. Receiving the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
• Breastfeeding: It’s not known whether it’s safe to receive Trodelvy while breastfeeding. There isn’t enough information to determine whether the drug passes into breast milk or what effects Trodelvy may have on a child who is breastfed. To be safe, your doctor may advise you to avoid breastfeeding during Trodelvy treatment and for at last 1 month after your last dose. If you’re breastfeeding or planning to, talk with your doctor before starting Trodelvy. They can talk with you about treatment options and ways to feed your child.
• Pregnancy: There haven’t been enough clinical trials to determine whether Trodelvy is safe to receive while pregnant. To be safe, your doctor isn’t likely to prescribe Trodelvy during pregnancy. If you or a partner can become pregnant, talk with your doctor before starting Trodelvy. They can advise you on birth control needs during and after Trodelvy treatment.

* Trodelvy has a boxed warning about the risk of severe or life threatening neutropenia. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous. For details, see “Boxed warnings” at the top of this article.

You can take certain steps to help prevent interactions with Trodelvy. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

• Let them know if you drink alcohol or use cannabis.
• Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
• Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Trodelvy label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Trodelvy doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

Besides learning about interactions, you may want to find out more about Trodelvy. These resources might help:

• Overview of Trodelvy: For a general overview of Trodelvy, you can see this article.
• Side effects: If you’re interested in the side effects of Trodelvy, see this article. Another option is to refer to Trodelvy’s prescribing information.
• Dosage specifics: To learn about the dosage of Trodelvy, see this article.
• Facts about your condition: To learn more about cancer, visit our cancer hub. For more information about breast cancer, see our breast cancer hub and list of breast cancer articles. To learn more about urothelial cancer (such as certain bladder cancers), refer to our list of urology and nephrology articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.