Treximet (sumatriptan/naproxen) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat migraine with or without aura. The drug is prescribed for adults as well as children ages 12 years and older.
Treximet comes as an oral tablet. It contains two active drugs: sumatriptan and naproxen. Sumatriptan belongs to a class of drugs known as triptans. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Treximet is available as a generic called sumatriptan/naproxen.
Dosage summary
The following chart summarizes Treximet’s dosage. Milligrams is abbreviated as mg. Your doctor will determine the dosage that’s best for you.
| Treximet form | Treximet strength | Typical dosage | Maximum dosage in 24 hours |
| oral tablet | 85 mg of sumatriptan/500 mg of naproxen | one 85-mg/500-mg tablet at the start of a migraine episode | two 85-mg/500-mg tablets taken at least 2 hours apart |
For information about Treximet dosages for migraine, including the drug’s strength and how to take the medication, keep reading. For a comprehensive look at Treximet, see this article.
This article describes typical dosages for Treximet provided by the drug’s manufacturer. When taking Treximet, always follow the dosage prescribed by your doctor.
Here’s some information about the dosages for Treximet.
Treximet form
Treximet comes as an oral tablet.
Treximet strength
Treximet has one strength. Each tablet contains 85 mg of sumatriptan and 500 mg of naproxen.
Typical dosages
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
The typical dose of Treximet for adults is one 85-milligram (mg)/500-mg tablet. It’s taken at the start of a migraine episode. If this dose doesn’t provide enough relief or if the migraine episode returns, you can take a second tablet 2 hours after the first tablet. However, if the first dose does not ease your migraine episode, you should not take a second dose. Instead, talk with your doctor.
The maximum dose in a 24-hour period is two tablets, taken at least 2 hours apart. Be sure to follow your doctor’s dosage directions for Treximet.
Children’s dosage
The maximum recommended dose of Treximet for children ages 12 years and older is one 85-mg/500-mg tablet. The drug is taken at the start of a migraine episode. It’s not known if treating more than two migraine episodes with Treximet every 30 days works or is safe in children.
The recommended dose of Treximet for children ages 12 years and older used to be one 10-mg/60-mg tablet. This strength is no longer available.
If you have questions about the Treximet dosage for your child, talk with their doctor.
Long-term treatment
Treximet is meant to be a long-term treatment. If you and your doctor determine that Treximet is safe and effective for you, you’ll likely take it long term.
Keep in mind that the safety of taking Treximet to treat a migraine headache more than five times in a 30-day period isn’t known. Talk with your doctor if you take Treximet more than five times during any 30-day period. You may benefit from a different medication for migraine headaches.
Be sure to follow your doctor’s dosage instructions for Treximet.
You’ll swallow Treximet tablets whole with a glass of water or other liquid. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.
Keep in mind that you can take Treximet with or without food.
Your doctor may have you take your first dose in their office if both of these situations apply:
- You have risk factors for cardiovascular side effects that Treximet may cause. (Cardiovascular refers to the heart and blood vessels.) These risk factors can include high blood pressure and diabetes.
- You do not have heart problems known as coronary artery disease and coronary artery spasm.
Taking your first dose in your doctor’s office allows them to monitor you for any side effects of Treximet. For more about side effects of the medication, see this article.
If your first dose doesn’t provide enough relief or if the migraine episode returns, you can take a second tablet 2 hours after the first tablet. However, if the first dose does not ease your migraine episode, you should not take a second dose. Instead, talk with your doctor. It’s important that you do not take more than two doses of Treximet in a 24-hour period.
Tracking migraine
Try to track when you have a migraine episode and when you take Treximet. This can help you learn if the medication is working. You can keep a written journal or enter the dates on a calendar on your phone. A migraine app may also be useful.
Accessible drug labels and containersIf you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.
If you’re having trouble opening medication bottles, ask your pharmacist about putting Treximet in an easy-open container. They also may recommend tools that can make it easier to open bottles.
The Treximet dosage your doctor prescribes will depend on several factors. These include:
- the type and severity of your migraine episodes
- how well your liver is working
- other medical conditions you may have
- your age
If you take more Treximet than your doctor prescribes, you may develop serious side effects.
It’s important that you do not take more Treximet than your doctor advises.
Symptoms of an overdose
One of Treximet’s active drugs is naproxen. Overdose symptoms of Treximet due to naproxen can include:
- extreme tiredness
- lack of energy
- nausea
- vomiting
- abdominal pain
- bleeding in the stomach or intestines
Overdose symptoms of Treximet that are rare can include:
- high blood pressure
- kidney failure
- difficulty breathing
- coma
If you take more than the recommended amount of Treximet
Call your doctor right away if you believe you’ve taken too much Treximet. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.
The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Treximet for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.
As with any drug, never change your dosage of Treximet without your doctor’s recommendation. If you have questions about the dosage of Treximet that’s right for you, talk with your doctor.
Besides learning about dosage, you may want other information about Treximet. These additional articles might be helpful:
- More about Treximet. For information about other aspects of Treximet, refer to this article.
- Drug comparison. Find out how Treximet compares with Imitrex and Zomig.
- Details about migraine. For specifics about migraine, see our headache and migraine hub and our list of related articles.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
