Tezspire (tezepelumab-ekko) is a brand-name drug prescribed for severe asthma in adults and some children. Tezspire comes as a solution for subcutaneous injection that’s given by you or a healthcare professional, typically every 4 weeks.

Tezspire is approved by the Food and Drug Administration (FDA) to treat severe asthma in adults and children ages 12 years and older. It’s typically given along with other asthma medications.

Tezspire is a biologic and belongs to a drug class called monoclonal antibodies. Tezspire isn’t available in a biosimilar version.

Keep reading for specific information about the dosage of Tezspire, including its strength and how to inject the medication. For a comprehensive look at Tezspire, see this article.

Note: This article describes the typical dosage for Tezspire provided by the drug’s manufacturer. If you self-inject Tezspire, always follow the dosage prescribed by your doctor.

Below is information about Tezspire’s form, strength, and dosage.

Tezspire form

Tezspire comes as a solution in single-dose vials, prefilled syringes, and prefilled pens. It’s given as a subcutaneous injection.

Your doctor or another healthcare professional will administer your first dose at the doctor’s office. Then, you and your doctor will decide whether you or a caregiver can inject your doses at home.

Tezspire strength

Tezspire comes in one strength of 210 milligrams (mg).

Typical dosage

The following information describes dosages that are commonly prescribed or recommended in adults. Your doctor will determine the best dosage to fit your needs.

Dosage for severe asthma

Doctors may prescribe Tezspire to treat severe asthma. The drug is typically prescribed along with other asthma drugs.

If your doctor prescribes Tezspire for severe asthma, your dose will likely be 210 mg by injection. Typically, you’ll receive this dose once every 4 weeks.

For more information about your specific dosage, talk with your doctor.

Children’s dosage

Tezspire is approved to treat severe asthma in children ages 12 years and older. The dosage is the same as the adult dosage. Your child will receive 210 mg by injection once every 4 weeks.

Talk with your child’s doctor if you have questions about their dosage.

Long-term treatment

Tezspire is meant to be a long-term treatment. If you and your doctor determine that Tezspire is safe and effective for you, you’ll likely receive it long term.

Before you start treatment with Tezspire, your doctor will discuss the medication with you.

Tezspire comes as a solution that’s given as a subcutaneous injection. The solution is available in a vial, prefilled syringe, and prefilled pen. If your doctor administers your injections at their office, they’ll use the vial or prefilled syringe. If you self-inject or a caregiver gives you the injection, your doctor will prescribe the prefilled pen.

With a subcutaneous injection, the medication is injected under your skin. A healthcare professional will show you how to use the Tezspire pen the first time.

If you keep Tezspire at home, you’ll store it in the refrigerator. You may store Tezspire at room temperature for up to 30 days if necessary. But do not put the medication back in the refrigerator after it has come to room temperature. If you haven’t used it within 30 days, properly discard the medication.

If you have questions about what to expect with your Tezspire injection, talk with your doctor or pharmacist. There’s also a helpful video and step-by-step instructions on the manufacturer’s website.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you miss a dose of Tezspire, inject it as soon as you remember and continue your regular dosing schedule.

But if it’s almost time for your next dose, skip the missed dose. Then give your next dose on the regularly scheduled day. Do not inject more than one dose per day. If you’re not sure whether you should inject a missed dose or skip it, talk with your doctor or pharmacist.

If you receive your Tezspire injection at your doctor’s office and miss an appointment, call the office as soon as possible to reschedule. They’ll adjust your dosing schedule if needed.

To help make sure that you don’t miss a dose or an appointment, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you don’t inject more Tezspire than your doctor prescribes. For some medications, using more than the recommended amount may lead to harmful effects or overdose.

If you inject more than the recommended amount of Tezspire

Call your doctor right away if you believe you’ve used too much Tezspire. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Tezspire.

Is the dosage of Tezspire similar to the dosage of Xolair?

No, there are differences in the timing of each dose and the strength. However, there are some similarities, including the drug form. Both Tezspire and Xolair (omalizumab) come as solutions for subcutaneous injection. After your initial doses by your doctor, you may be able to self-inject the drug. Xolair also comes in another form that your doctor prepares and administers.

Tezspire is injected once every 4 weeks. Xolair may be injected once every 2 weeks or 4 weeks, depending on the condition it’s prescribed for. Both medications are approved to treat severe asthma. Xolair also has other approved uses, including treatment of nasal polyps.

The dose in milligrams for each drug also differs because they have different active ingredients. In children, the dosage of Xolair is based on body weight, but Tezspire’s dosage is not. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Tezspire to start working?

Tezspire starts to work after your first dose. But it may take anywhere from 2 weeks to several months for your asthma symptoms to ease. Your doctor will monitor you during treatment to check whether the drug is working to reduce your symptoms.

You may want to keep a diary of your symptoms to share with your doctor. This may help determine whether the medication is improving your asthma.

Talk with your doctor if you have questions about what to expect with Tezspire treatment.

The dosage in this article is the typical dosage provided by the drug’s manufacturer. If your doctor recommends Tezspire for you, they’ll prescribe the dosage that’s right for you. If you self-inject Tezspire, always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Tezspire without your doctor’s recommendation. If you have questions about the dosage of Tezspire that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Tezspire. These additional articles might be helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.