Talvey (talquetamab-tgvs) is a brand-name injection that’s prescribed for multiple myeloma in certain adults. Talvey may have interactions with some other drugs. Examples include warfarin.

An interaction occurs when one substance causes another substance to have a different effect than expected.

To learn more about Talvey’s interactions, keep reading. For additional information about Talvey, including details about its uses, see this article.

Before you start treatment with Talvey, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Talvey interacts with supplements, herbs, or vitamins, see the “Talvey and other interactions” section below.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a table of drugs that can interact with Talvey. Keep in mind that this table doesn’t include all drugs that may interact with Talvey. For details about the following drug interaction, see the “Drug interactions in depth” section below.

Drug type or drug nameDrug examplesInteraction result with Talvey
certain drugs broken down by cytochrome P450 enzymescarbamazepine (Tegretol, others)
cyclosporine (Neoral, others)
phenytoin (Dilantin)
• theophylline (Theo-24, others)
warfarin (Jantoven)
can increase the risk of side effects from these drugs

There aren’t any known interactions between Talvey and alcohol. However, if you drink alcohol, your doctor may advise you to avoid or limit consumption during Talvey treatment.

This is because drinking alcohol while receiving the drug may worsen some of Talvey’s side effects. For example, you may experience:

In addition, consuming large amounts of alcohol can cause liver damage. Talvey may also cause liver damage as a side effect.* This means that drinking alcohol during Talvey treatment may increase the risk of liver problems.

If you consume alcohol during Talvey treatment, these side effects may be more likely to occur. If you have questions about drinking alcohol during Talvey treatment, talk with your doctor.

* To learn about Talvey’s side effects, see this article.

Here’s a closer look at certain drug interactions of Talvey.

Medications broken down by cytochrome P450 enzymes

Cytochrome P450 (CYP) enzymes are proteins that break down many different drugs and help clear them from your body. Drugs cleared from your body in this way are called CYP substrates.

Talvey can interact with certain CYP substrates.

Interaction result: Receiving Talvey with certain CYP substrates (medications) could raise your risk of side effects from the CYP substrate.

Interaction explained: Talvey causes proteins called cytokines to be released into your blood. These cytokines can stop CYP enzymes from working as well as usual.

Receiving Talvey with a medication that’s a CYP substrate could slow the breakdown of the CYP substrate. If the drug breaks down slower, it may build up in your body. With some medications, even a small increase in the amount of the drug in your body can raise your risk of its side effects.

This interaction is most likely to occur when you start treatment with Talvey, or if you have a side effect called cytokine release syndrome (CRS) with Talvey.*

Drug examples: Here are some CYP substrates that may interact with Talvey:

Steps you or your doctor may take: If your doctor prescribes a CYP substrate (such as any medications listed above), be sure they know that you’re receiving Talvey. They’ll likely monitor you more closely for drug interactions (side effects of the CYP substrate). If needed, your doctor may adjust your dosage of the CYP substrate. You should also review all the medications you take with the doctor who’s prescribing Talvey.

If you have questions or concerns about Talvey interacting with a CYP substrate or any other medication, talk with your doctor or pharmacist.

* Talvey has a boxed warning about CRS. For more information, see “boxed warnings” at the start of this article.

Talvey may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Talvey.

Talvey and supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Talvey and herbs

There are no specific reports of herbs interacting with Talvey. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during your Talvey treatment.

Talvey and vitamins

There are no specific reports of vitamins interacting with Talvey. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Talvey.

Talvey and food

There were no reports of food interactions with Talvey. If you’d like to learn more about eating certain foods during treatment with Talvey, talk with your doctor.

Talvey interactions with vaccines

It’s not known for certain whether Talvey interacts with live vaccines. The drug wasn’t studied with live vaccines in clinical trials.

A live vaccine contains live but weakened pieces of the virus or bacterium it’s meant to defend against. When your immune system is healthy, live vaccines usually won’t cause infection. But Talvey can weaken your immune system. So if you get a live vaccine, your immune system may not be able to fight the virus or bacterium. This may cause you to become sick or develop symptoms of the illness the vaccine is meant to prevent.

Examples of live vaccines to avoid during Talvey treatment include:

Before starting Talvey, talk with your doctor or pharmacist about any vaccines you may need.

Talvey interactions with lab tests

Talvey isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.


Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Talvey. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Talvey. The impact of cannabis may affect how well you stick to your Talvey treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Talvey. Before you start this medication, be sure to talk with your doctor about your health history. Talvey may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Talvey include:

  • Low white blood cell or platelet counts: Talvey can lower your white blood cell and platelet counts. If you have a low white blood cell or platelet count, your doctor will determine whether this medication is right for you.
  • Infections: Talvey can raise your risk of infections, including serious and even life threatening infections. Before starting Talvey, tell your doctor if you have an active infection or infections that keep coming back. Your doctor may prescribe medication to treat or help prevent infections during Talvey treatment.
  • Liver problems: Talvey can affect your liver. If you have an existing liver problem, Talvey could make it worse. Talk with your doctor about whether this medication is right for you.
  • Allergic reaction: If you’ve had an allergic reaction to Talvey or any of its ingredients, your doctor will likely not prescribe Talvey. Receiving the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.
  • Breastfeeding: You should not breastfeed while receiving Talvey and for 3 months after your last dose. If you’re breastfeeding or planning to, talk with your doctor. They can talk with you about treatment options and ways to feed your child.
  • Pregnancy: Talvey is not safe to receive while pregnant. The medication could cause fetal harm if used during pregnancy. If you’re pregnant or planning to become pregnant, talk with your doctor about your treatment options. If you’re able to become pregnant, you should use birth control during Talvey treatment and for 3 months after your last dose.

You can take certain steps to help prevent interactions with Talvey. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

  • Let them know if you drink alcohol or use cannabis.
  • Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
  • Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Talvey label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Talvey doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

Besides learning about interactions, you may want to find out more about Talvey. These resources might help:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.