Stiolto Respimat (tiotropium bromide and olodaterol) is a brand-name drug that’s prescribed for chronic obstructive pulmonary disease (COPD) in adults. Stiolto Respimat comes as an inhaler that’s typically taken once per day.

Stiolto Respimat is a combination drug. It belongs to two drug classes called anticholinergics and long-acting beta2-agonists (LABAs). Stiolto Respimat is not available in a generic version.

Keep reading for specific information about the dosage of Stiolto Respimat, including its strength and how to take the medication. For a comprehensive look at Stiolto Respimat, see this article.

Note: This article describes typical dosages for Stiolto Respimat provided by the drug’s manufacturer. When taking Stiolto Respimat, always follow the dosage prescribed by your doctor.

The information below describes Stiolto Respimat’s typical dosage and other details about the drug.

Stiolto Respimat form

Stiolto Respimat comes as a metered-dose inhaler.

Stiolto Respimat strength

Stiolto Respimat comes in one strength. Each puff of Stiolto Respimat contains 2.5 micrograms (mcg) of tiotropium and 2.5 mcg of olodaterol. Typically, you will take two puffs for a total dosage of 5 mcg of tiotropium and 5 mcg of olodaterol.

Typical dosages

Typically, the dosage for COPD is two puffs once per day.

The following information describes dosages that are commonly prescribed in adults. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for chronic obstructive pulmonary disease

Doctors may prescribe Stiolto Respimat to treat chronic obstructive pulmonary disease (COPD).

If your doctor prescribes Stiolto Respimat for your COPD, your starting dose will likely be two puffs taken back to back. Typically, you’ll take the dosage of two puffs once a day around the same time each day. This is the typical recommended dosage of Stiolto Respimat for people with COPD. This is also the maximum dose of Stiolto Respimat that’s recommended.

For more information about your specific dosage, talk with your doctor.

Long-term treatment

Stiolto Respimat is meant to be used as a long-term treatment. If you and your doctor determine that Stiolto Respimat is safe and effective for you, you’ll likely use it long term.

Before you start taking Stiolto Respimat, your doctor will discuss your treatment plan with you.

The Stiolto Respimat dosage your doctor prescribes will depend on several factors. These include:

  • how your body responds to Stiolto Respimat
  • side effects you may have with Stiolto Respimat

Other medical conditions you have can also affect your Stiolto Respimat dosage.

Dosage adjustments

The typical dosage for COPD is two puffs once a day. This is also the maximum dosage. It is not recommended to take more than two puffs in a 24-hour period. If you are still experiencing symptoms of COPD while using Stiolto Respimat, talk with your doctor.

Stiolto Respimat comes as an inhaler that’s typically taken once per day as two puffs back to back. It’s important to take Stiolto Respimat around the same time each day to keep a steady level of the drug in your body.

Take Stiolto Respimat according to your healthcare professional’s instructions. When you first get your prescription for Stiolto Respimat, your healthcare professional will explain how to use your inhaler.

Stiolto Respimat is a two-piece device you must put together to deliver your medication through the inhaler. Stiolto Respimat must be put together before you start using it for the first time and each time you get a refill. The two pieces that must be put together are the:

  • inhaler device
  • medication cartridge that contains the active ingredients in Stiolto Respimat (tiotropium and olodaterol)

If you have trouble inhaling your medication, see “General guidance” below for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

General guidance:

If you have questions about how to use Stiolto Respimat, talk with your doctor or pharmacist. There’s also a helpful video, step-by-step instructions of how to use the inhaler, and step-by-step instructions on how to set up your inhaler for the first time on the manufacturer’s website.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you miss a dose of Stiolto Respimat, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and take your next scheduled dose. Do not take two doses to make up for the missed one. And do not take more than one dose in 24 hours. If you’re not sure whether you should take a missed dose or skip it, talk with your doctor or pharmacist.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

It’s important that you don’t take more Stiolto Respimat than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

Symptoms of an overdose

Overdose symptoms and effects of Stiolto Respimat can include:

If you take more than the recommended amount of Stiolto Respimat

Call your doctor right away if you believe you’ve taken too much Stiolto Respimat. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Stiolto Respimat.

Is the dosage of Stiolto Respimat similar to the dosage of other similar drugs, such as Symbicort?

Both Stiolto Respimat and Symbicort (budesonide and formoterol fumarate dihydrate) are approved for treating chronic obstructive pulmonary disease (COPD) in adults. But Symbicort is also approved to treat asthma in people 6 years of age and older.

Stiolto Respimat and Symbicort are both metered dose inhalers, but they are not taken at the same frequency. Stiolto Respimat is taken once a day, whereas Symbicort is taken twice a day.

Stiolto Respimat comes in one strength, and Symbicort comes in two strengths. Stiolto Respimat contains an anticholinergic medication and a long-acting beta2-agonist medication, while Symbicort contains an inhaled steroid medication and a long-active beta2-agonist medication.

The dose in milligrams for each drug differs because they have different active ingredients. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

Can Stiolto Respimat be used for asthma? If so, what’s the dosage?

No, Stiolto Respimat is not used for asthma. It is also not used for sudden breathing problems caused by COPD.

Because Stiolto Respimat isn’t used for asthma, the drug’s manufacturer doesn’t provide recommended dosages for this use.

However, Symbicort is a drug that’s approved for asthma. If you have questions about managing asthma, talk with your doctor. They can recommend treatment options for your asthma.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Stiolto Respimat for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Stiolto Respimat without your doctor’s recommendation. If you have questions about the dosage of Stiolto Respimat that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Stiolto Respimat. These additional articles might be helpful:

  • More about Stiolto Respimat: For information about other aspects of Stiolto Respimat, refer to this article.
  • Side effects: To learn about side effects of Stiolto Respimat, you can also look at the Stiolto Respimat prescribing information.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.