Myfembree (relugolix, estradiol, and norethindrone) is a brand-name drug that’s prescribed for specific symptoms related to uterine fibroids and endometriosis in certain adults. Myfembree comes as an oral tablet that’s typically taken once per day.

Myfembree is approved by the Food and Drug Administration (FDA) to treat females* who have not yet experienced menopause with:

Sex and gender exist on spectrums. Use of the term “female” in this article refers to sex assigned at birth.

Myfembree is a combination of three active ingredients, which belong to different drug classes. Relugolix is a gonadotropin-releasing hormone receptor antagonist (GnRH blocker). Estradiol and norethindrone are hormones: Estradiol is an estrogen, and norethindrone is a progestin. Myfembree isn’t available in a generic version.

Keep reading for specific information about the dosage of Myfembree, including its strength and how to take the medication. For a comprehensive look at Myfembree, see this article.

Note: This article describes typical dosages for Myfembree provided by the drug’s manufacturer. When taking Myfembree, always follow the dosage prescribed by your doctor.

Below is information about Myfembree’s form, strength, and dosage.

Myfembree form

Myfembree comes as an oral tablet.

Myfembree strength

Myfembree comes in one strength combining its three drugs. Each tablet of Myfembree is a fixed-dose combination of the three active ingredients: 40 milligrams (mg) of relugolix, 1 mg of estradiol, and 0.5 mg of norethindrone acetate.

Typical dosages

The following information describes dosages that are commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for heavy periods related to uterine fibroids

Doctors may prescribe Myfembree to help manage heavy periods that are related to fibroids. The typical recommended Myfembree dosage for this use is one tablet by mouth once per day.

Certain drugs interact with Myfembree. If you take them, your doctor may prescribe a dosing schedule. Typically, they’ll recommend dosing them at least 6 hours after Myfembree. (See the “Interactions” section of this article.)

For more information about your specific dosage, talk with your doctor.

Dosage for pain related to endometriosis

Myfembree is also approved to help manage moderate to severe pain caused by endometriosis. The typical recommended Myfembree dosage for this use is one tablet by mouth once per day.

Certain drugs interact with Myfembree. If you take them, your doctor may prescribe a dosing schedule. Typically, they’ll recommend dosing them at least 6 hours after Myfembree. (See the “Interactions” section of this article.)

Talk with your doctor if you have questions about your dosage.

How to take Myfembree

This drug comes as a tablet that you swallow whole. You’ll take the first dose as soon as possible after your period starts or within 7 days after. This will help you avoid a heavy or irregular period early in treatment. Then, you’ll take one tablet at the same time each day, with or without food.

While taking Myfembree, tell your doctor about all prescriptions, drugs, and supplements you take. Keep up on routine screenings. Your doctor may confirm that you are not pregnant before starting treatment with Myfembree. They may recommended certain birth control methods that are needed during and after treatment.

Some effects of Myfembree may not be reversible. During treatment, tell your doctor right away about any symptoms, changes, or Myfembree side effects you notice, including:

If you have thoughts of suicide during treatment, call 911 or your local emergency number. In the United States, you can also call the Suicide and Crisis Lifeline at 988 or text HOME to the Crisis Textline at 741741. You can also refer to this article for ways to seek support.

If you have questions about how to take Myfembree, talk with your doctor or pharmacist. There’s also patient information and instructions on the manufacturer’s website.

Long-term treatment

Myfembree is meant to be taken as a long-term treatment. However, Myfembree can cause bone loss that may not be reversible. Due to this risk, treatment is usually limited to 24 months. If you and your doctor feel Myfembree is safe and effective for you, you’ll likely take it for 24 months or less.

Before you start taking Myfembree, your doctor will discuss your treatment plan with you.


Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Myfembree in an easy-open container. They also may recommend tools that can make it easier to open bottles.

It’s important that you do not take more Myfembree than your doctor prescribes. For some medications, taking more than the recommended amount may lead to harmful effects or overdose.

Effects of an overdose

Overdose effects of Myfembree can include:

If you take more than the recommended amount of Myfembree

Call your doctor right away if you believe you’ve taken too much Myfembree. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Below are some frequently asked questions about Myfembree.

How long does it take Myfembree to start working?

Myfembree starts to work after your first dose. However, because of how it works, you likely won’t notice your symptoms getting better right away. Heavy periods and endometriosis pain may take a matter of weeks or months to improve.

According to clinical studies, some improvement in symptoms was seen as early as week 4. Still, it may take longer for you to feel Myfembree’s full effect. Talk with your doctor if you’ve taken it regularly for 8 to 12 weeks and don’t feel any better.

Ask your doctor any questions you have about what to expect with Myfembree treatment.

Is Myfembree approved for weight loss? If so, what’s the dosage?

No, Myfembree is not approved for weight loss. Additionally, weight changes aren’t listed as a side effect of Myfembree in the prescribing information.

At present, Myfembree is only approved for two uses. These uses are heavy periods related to fibroids and moderate to severe pain from endometriosis. Only these uses have recommended doses in the prescribing information.

If you have concerns or questions about your weight, talk with your doctor. They can provide information or recommend options appropriate for you.

Does Myfembree stop your period? If so, at what dosage?

People taking Myfembree may experience amenorrhea (no periods). However, in clinical studies, Myfembree didn’t stop periods in everyone who took it, but some noticed that their periods became lighter or shorter.

If you’d like to learn more about Myfembree and what it can do, talk with your doctor.

Does Myfembree shrink fibroids? If so, at what dosage?

No. Myfembree is meant to address a symptom of fibroids, not the fibroids themselves. Myfembree isn’t approved to shrink fibroids. The goal of Myfembree treatment is to help manage heavy periods related to uterine fibroids. The dosage for heavy periods caused by fibroids is one tablet once per day.

If you have questions about how to treat fibroids, talk with your doctor. They can recommend options to address them.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.