Leflunomide is a generic oral tablet that’s prescribed for active rheumatoid arthritis (RA) in adults. It’s available as the brand-name drug Arava. The cost of leflunomide with and without insurance can depend on several factors.

As with all medications, the cost of leflunomide can vary. Factors that may affect the price you’ll pay include your treatment plan, your insurance coverage, and the pharmacy you use.

To find out what the cost of leflunomide will be for you, talk with your doctor, pharmacist, or insurance provider. Or look below in the next section to learn how much you can save by using an Optum Perks coupon.

To save money on your leflunomide prescription, explore these Optum Perks coupons.

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Retail price refers to the manufacturer’s published list price and is up to date as of 3/2023. Retail and discounted prices are U.S.-only and can vary based on region and pharmacy. We cannot guarantee that the discounted price listed here will exactly match the price at your pharmacy. Please contact your pharmacy for the exact price.

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Leflunomide is a generic drug, which means it’s an exact copy of the active ingredient in a brand-name medication. A generic drug is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs.

Leflunomide is available as the brand-name drug Arava. If your doctor has prescribed leflunomide and you’re interested in Arava instead, talk with your doctor. They may prefer one version or the other. You’ll also need to check with your insurance provider, as it may cover only one or the other.

To find out how the cost of this brand-name drug compares with the cost of leflunomide, talk with your doctor, pharmacist, or insurance provider.

If you take leflunomide long term, you may be able to lower its cost in the following ways.

Getting a 3-month supply

You may be able to get a 90-day supply of leflunomide. If approved by your insurance company, getting a 90-day supply of the drug could reduce your number of trips to the pharmacy and help lower the cost. If you’re interested in this option, check with your doctor, pharmacist, or insurance provider.

Using a mail-order pharmacy

Leflunomide may be available through a mail-order pharmacy. Using this type of service may help lower the drug’s cost and allow you to receive your medication without leaving home. Some Medicare plans may help cover the cost of mail-order medications. You may also be able to get a 90-day supply of the drug via mail order.

If you don’t have health insurance, talk with your doctor or pharmacist. They may be able to suggest online pharmacy options that could work for you.

If you need financial support to pay for leflunomide, consider looking into websites that offer cost resources and information. Two such organizations are:

These sites can provide details about drug assistance programs, ways to make the most of your insurance coverage, and links to savings cards and other services.

Here are answers to some frequently asked questions about drug cost and leflunomide.

How does leflunomide’s cost compare with that of medications such as methotrexate?

The price you would pay for leflunomide versus that of methotrexate depends on various factors. For instance, the form of the drug may affect its price. Leflunomide is available as an oral tablet. Methotrexate is available as an oral tablet, oral solution, and in certain injectable forms. Typically, injectable drugs cost more than tablets.

Additional factors that can affect your prescription cost include:

  • the length of your treatment
  • whether there are payment assistance programs for your prescribed treatment
  • whether you’re paying out of pocket or have insurance

To learn more about the cost of leflunomide compared with other treatments for your condition, talk with your doctor, pharmacist, or insurance provider.

What is the cost of leflunomide without insurance?

Leflunomide’s cost without insurance can vary based on several factors. But typically, the cost is higher for those without insurance. Factors that could affect what you pay for this drug include:

  • the quantity you’re prescribed (such as a 90-day or 30-day supply)
  • whether you apply and qualify for any available savings programs
  • your dosage
  • the pharmacy you use

To learn the exact cost you’d pay for this medication without insurance, ask your doctor or pharmacist. You may also want to contact several pharmacies to compare their prices for leflunomide.

Check out Optum Perks* for estimates of leflunomide’s price when using coupons from the site. (Optum Perks coupons cannot be used with insurance benefits or copays.)

* Optum Perks is a sister site of Medical News Today.

Below is information you may want to consider if you have insurance and receive leflunomide.

If you have insurance, your insurance company may require prior authorization before it covers leflunomide. This means the company and your doctor will discuss leflunomide in regard to your treatment. The insurance company will then determine whether to cover the medication. If a drug requires prior authorization but you start treatment without the prior approval, you could pay the full cost of the medication. You can ask your insurance company whether leflunomide requires prior authorization.

Now that you’ve learned about cost and leflunomide, you may still have some questions. Talk with your doctor or pharmacist, who can provide personalized guidance about cost issues related to leflunomide. But if you have health insurance, you’ll need to talk with your insurance provider to learn the actual cost you would pay for leflunomide.

Here are some other resources you may find helpful:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.