Jemperli (dostarlimab-gxly) is a brand-name intravenous infusion. It’s prescribed for endometrial cancer and solid tumors in certain situations. Jemperli isn’t known to interact with alcohol, other drugs, or supplements. However, Jemperli has certain health-related interactions.

An interaction occurs when one substance causes another substance to have a different effect than expected.

To learn more about Jemperli’s interactions, keep reading. For additional information about Jemperli, including details about its uses, see this article.

It isn’t known for certain whether Jemperli interacts with other medications. The drug’s manufacturer did not look at interactions in clinical trials.

However, it is possible that new interactions may be recognized in the future. For example, people who’ve received Jemperli since it became available could report a suspected interaction.

Before you start treatment with Jemperli, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Jemperli interacts with supplements, herbs, or vitamins, see the “Jemperli and other interactions” section below.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

There are no known interactions between Jemperli and alcohol. However, your doctor may advise you to avoid or limit alcohol consumption during Jemperli treatment.

This is because drinking alcohol while taking the drug may worsen some of Jemperli’s side effects. For example, you may experience worsened fatigue, nausea, or vomiting.

In addition, consuming large amounts of alcohol can cause liver damage. Jemperli may cause hepatitis (liver inflammation) as a side effect. Drinking large amounts of alcohol during Jemperli treatment may worsen this liver condition.

If you have questions about drinking alcohol during Jemperli treatment, talk with your doctor.

Jemperli may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Jemperli.

Jemperli and supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Jemperli and herbs

There are no specific reports of herbs interacting with Jemperli. However, that doesn’t mean herbal interactions won’t occur or be recognized in the future. Because of this, it’s important to check with your doctor or pharmacist before taking any of these products during Jemperli treatment.

Jemperli and vitamins

There are no specific reports of vitamins interacting with Jemperli. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Jemperli.

Jemperli and food

There were no reports of food interactions with Jemperli. If you’d like to learn more about eating certain foods during treatment with Jemperli, talk with your doctor.

Jemperli and vaccines

There aren’t any known interactions between Jemperli and vaccines. Talk with your doctor or pharmacist to see whether you’re due for any vaccines.

Jemperli and lab tests

Jemperli isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.


Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Jemperli. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Jemperli. The impact of cannabis may affect how well you stick to your Jemperli treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Jemperli. Before you take this drug, be sure to talk with your doctor about your health history. Jemperli may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Jemperli include:

  • Chest radiation therapy: Jemperli may cause pneumonitis as a serious side effect. This risk may be increased for people who’ve had radiation therapy to the chest. Tell your doctor if you’ve ever had chest radiation therapy. They can recommend whether Jemperli should be part of your treatment plan.
  • Stem cell transplant: Having a stem cell transplant before or after Jemperli treatment may result in serious transplant-related side effects. This risk applies to transplants in which stem cells are taken from a donor. If you’ve had a stem cell transplant or are planning to, talk with your doctor to determine whether Jemperli is safe for you.
  • Organ transplant: If you’ve had an organ transplant, talk with your doctor before using Jemperli. The drug may increase the risk of transplant rejection (when the immune system attacks a transplanted organ). Talk with your doctor about whether Jemperli is the right treatment option for you.
  • Allergic reaction: If you’ve had an allergic reaction to Jemperli or any of its ingredients, your doctor will likely not prescribe Jemperli. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
  • Breastfeeding: It’s likely not safe to use Jemperli while breastfeeding. If you’re breastfeeding or planning to, talk with your doctor before using Jemperli. They can talk with you about treatment options and ways to feed your child.
  • Pregnancy: Jemperli is likely unsafe to use while pregnant. Because of how the drug works in the body, it may cause pregnancy loss. If you’re pregnant or planning to become pregnant, tell your doctor before starting Jemperli. They can advise you on the right treatment plan for you.

You can take certain steps to help prevent interactions with Jemperli. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

  • Let them know if you drink alcohol or use cannabis.
  • Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
  • Create a medication list, which your doctor and pharmacist can help you fill out.

It’s also important to read the Jemperli label and other paperwork that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Jemperli doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

Besides learning about interactions, you may want to find out more about Jemperli. These resources might help:

  • Overview of Jemperli:For a general overview of Jemperli, you can see this article.
  • Side effects:If you’re interested in the side effects of Jemperli, see this article. Another option is to refer to the Jemperli prescribing information.
  • Dosage specifics: To learn about the dosage of Jemperli, see this article.
  • Facts about your condition: To learn more about endometrial cancer and other cancers, see our list of cancer articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.