Jemperli (dostarlimab-gxly) is a brand-name drug that’s prescribed for certain types of cancers in adults. Jemperli comes as a liquid for intravenous (IV) infusion that’s given by a healthcare professional. It’s typically given once every 3 or 6 weeks.

Jemperli is approved by the Food and Drug Administration (FDA) to treat:

Jemperli is a biologic drug. It belongs to a drug class called immune checkpoint inhibitors. Jemperli is not available in a biosimilar version.

Keep reading for specific information about the dosage of Jemperli, including its strength and how it’s given. For a comprehensive look at Jemperli, see this article.

Note: This article describes the typical dosages for Jemperli provided by the drug’s manufacturer. However, your doctor will prescribe the Jemperli dosage that’s right for you.

The typical recommended dosages for Jemperli are described below.

Jemperli form

Jemperli comes as a solution that’s given as an IV infusion. It’s always given by a healthcare professional.

Jemperli strength

Jemperli comes in one strength: 500 milligrams per 10 milliliters of solution (mg/mL). It comes in a single-dose vial.

Typical dosages

The following information describes dosages that are commonly prescribed or recommended. Your doctor will determine the best dosage to fit your needs.

Dosage for endometrial cancer

Doctors may prescribe Jemperli to treat endometrial cancer. Jemperli may be prescribed in combination with other chemotherapy treatments in some situations.

When Jemperli is prescribed alone: The typical dosage is 500 mg every 3 weeks for four doses, followed by 1,000 mg every 6 weeks.

When Jemperli is prescribed with carboplatin and paclitaxel: The typical dosage is 500 mg every 3 weeks for six doses (along with carboplatin and paclitaxel), followed by 1,000 mg of Jemperli alone every 6 weeks.

For more information about your specific dosage, talk with your doctor.

Dosage for mismatch repair deficient recurrent or advanced solid tumors

The typical dosage of Jemperli for certain solid tumors, including mismatch repair deficient (dMMR)* recurrent or advanced solid tumors, is 500 mg every 3 weeks for four doses, followed by 1,000 mg every 6 weeks. Solid tumors may include liver, colorectal, or breast cancer. Recurrent or advanced tumors have gotten worse during treatment or have come back after another treatment.

For more information about your specific dosage, talk with your doctor.

* Cancers that are dMMR have certain genetic abnormalities that prevent the DNA from fixing itself inside of cells. In typical cells, DNA or genes help to repair any abnormal activity. Without the ability to fix these genetic abnormalities, there is an increased risk of cancer.

Long-term treatment

Jemperli is meant to be a long-term treatment. If you and your doctor determine that Jemperli is safe and effective for you, you’ll likely receive it long term.

Your doctor will discuss your treatment plan with you before you start Jemperli.

Your doctor or another healthcare professional will give you the IV infusion of Jemperli. You’ll likely go to your doctor’s office, infusion center, or a hospital to receive your infusion. The infusion takes about 30 minutes.

If you miss your appointment for a Jemperli infusion, call your doctor’s office as soon as possible to reschedule. They’ll adjust your dosing schedule as needed.

If you need help remembering your appointments, try setting an alarm or downloading a reminder app on your phone.

Below are some frequently asked questions about Jemperli.

Is the dosage of Jemperli similar to the dosage of Keytruda?

Yes, the forms and how often you receive each drug are similar. Jemperli and Keytruda (pembrolizumab) are both given as an IV infusion by a healthcare professional every 3 or 6 weeks.

The dose in mg for each drug differs because they have different active ingredients. Your doctor will prescribe the drug and the dosage that’s right for you.

To learn more about how these drugs compare, talk with your doctor.

How long does it take for Jemperli to start working?

Jemperli starts to work after your first dose. Because of how the drug works, you likely won’t feel the drug working in your body. Your doctor will monitor you during treatment to check whether the drug is working to treat your condition. It may be several months before you know how well the drug is working.

Talk with your doctor if you have questions about what to expect with Jemperli treatment.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Jemperli for you, they will prescribe the dosage that’s right for you.

Besides learning about dosage, you may want other information about Jemperli. These additional articles might be helpful:

  • More about Jemperli: For information about other aspects of Jemperli, refer to this article.
  • Side effects: To learn about side effects of Jemperli, see this article. You can also look at the Jemperli prescribing information.
  • Details about your condition: For details about your condition, see our cancer hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.